We rode about 300 miles of the Divide in Colorado. I pulled a BOB Ibex behind my full suspension bike. My son rode hard tail 29er with rear panniers and Revelate sweet roll. Wife had similar luggage on full suspension bike. Friend rode Pugsley fat bike with panniers, frame bag, and sweet roll. So we were trying many combinations of bikes and gear.
My conclusions:
The full suspension and trailer literally bob going up hills and the rig saps a lot of energy. The trailer lurches going over obstructions on up hills, making the climbing even harder. Down hills were fine and the rig was stable, something I had worried about. You can pack a lot of gear and the loading and unloading in camp are easy.  However, access to items during the day are kind of a pain because of all the closure mechanism and bungies (I was using the BOB dry bag.)
My sons set up was the lightest and probably fastest. We did load him up with some heavy items to try to slow him down. The panniers and sweet roll provided some balance to the load. He said the hard tail was a bit jarring at times.
My wife's full suspension and pannier/sweet roll combo gave probably the smoothest ride. Load capacity was good and this seems like it may be a good balance of overall weight and comfort.
Our friend on the fat bike is a strong rider and was carrying one of the heavier loads. He had 3.8 inch tires and ran about 20-25 psi. This set up worked well for him and was definitely the most stable on gravel descents and stream crossings. He has since completed a 400 mile endurance ride with this same bike but with all Revelate bags and 3 inch tires. He was quite happy with that setup and it was surprisingly light.
The destruction of wheels on fully loaded bikes on longer rides, as was mentioned by a previous poster, definitely is a concern.  Those wheels, especially the rear, are loaded. If you travel heavy a trailer might be for you.
What conclusions did I draw? No trailer for me. The trailer and dry bag weigh about 16 lbs. empty. It's another wheel generating rolling resistance. My joking conclusion was that it was like towing a fat kid on a skateboard behind you.
My next section of the Divide I'm planning to ride on a fat bike with 3 inch tires and possibly a suspension fork. Luggage will likely be panniers, frame bag, and sweet roll. This should distribute the weight and keep it low. If I were younger, I might go more minimalist, but at my age I want a little more comfort in camp.