Usually works out well! I would get a sturdy pair of wheels, for the added weight you'll be hauling. I would get something hand built, and no-frills. 32 hole (or maybe more, but that's not too important unless you're carrying a TON), REGULAR spokes, decent hubs. A good wheel builder would be able to point you in the right direction.
Saddle bags for MTB bikepacking should work well, but double-check they're not too tall to work with the amount of seatpost you've got showing,
There's off the shelf and custom frame bags that should work well with a road frame, check out the half bags so you can still use waterbottle holders.
Road style bars do pose a problem. Putting a handlebar harness for a stuff sack would mean you're running a fairly narrow stuff sack, which may not be ideal. You could do a few things: Run a front rack, if your fork supports that, use a pack, or swap out your bars for something else that's wider and/or flared. You may lose some hand positions whatever you do for bullhorn-type bars, though. Drops will probably work, unless you're squeezing a bag in there. On the hoods will work OK, but you're probably SOL on the tops. Your cable setup may need some work to deal with a stuff sack in the way. Totally doable. You could also swap the bullhorns for something else, but then you may have to swap your brifters for something else, and all of a sudden, it's a lot of work!
Anyways, it's totally doable. Check out the Trans Am instgram for inspiration,
https://www.instagram.com/transambikerace/