I made all but one piece for my bikepacking bike. When I rode the Tour Divide route a few weeks back, I loaded it like this.
The seat bag is a Rogue Panda Picketpost - In it I put all of my clothing. A spare base layer bottom and top, a silk layer(never used), spare bib shorts, socks, a fleece top, regular shorts, my surly cap and even a can of soup and 2 cans of tuna. Oftentimes anything that would fit went into it. The Picketpost NEVER swayed on me EVER! I rate it an A+.
My homemade frame bag is not waterproof - It held a small dry bag containing tools, small spare parts, cables, etc... and a small ziploc acting as a a small first aid kit. I also fit in there 2 spare tubes (laid out they make good padding), a tire pump, power bars and similar, once or twice a 1 liter soft bottle for extra water, A pack of wet wipes and a few other small items here and there.
My front handlebar roll bag is homemade. It held my tent (which was heavier than I wanted), a Klymit sleeping pad and an Outdoor Essentials 20 degree sleeping bag. My roll bag is a bit tricky to get mounted and use (a bit of a redesign is needed) but it was absolutely rock solid the entire time that I spent on the TD route.
Strapped in front of the roll bag is a 3 compartment mesh apron. One pouch held maps and a flat Werner(long story), the middle held my Delorme InReach unit, and the last was bear spray and waterproof camera.
In the image, you can see my front saddle bags? They are similar to a gas tank, but extend down along the front of the frame bag. They are similar to feed bags. The left side held quick access items. Chamois butt'r, personal necessity items, spare batteries, other small items here and there. The right side held a Romoss battery pack for charging USB devices as well as necessary USB cables. Right between the 2 was a USB Werks unit to control the dynamo charging.
I also had an Outdoor Research lightweight backpack. In it was medications that I might need, rain jacket, a few small bags of trail mix, a soft water bottle once or twice, a Sawyer mini filter. I tried to keep the backpack light.
On my TD ride, I learned things to do and not to do on the way. There were things that were always in the way. A good overnighter for a day or two is a great way to find these things out. Looking back, my gear loadout will change depending on the forecast weather. Dry riding is simple, wet riding adds an extra level of complexity.
Oh yeah, a pair of Croc clones strapped to the seat bag. Light and I can ride my flats with them. Good for crossings where you feet will get wet. I like to keep dry shoes if at all possible.