Yes, if you keep your wits about you.
On my 2006 trip I was able to follow a track track that Scott laid out for me with no cue sheet and only a basic map as a back up.
So far I don't think anybody's gotten lost while doing the 300, missed the course and came back in from the wrong direction sure, but not lost.
Just make sure you find the TH for the start and you'll be fine. Scott does not provide any beta on how to get there for a reason.
If you can't find the TH you don't need to go.